Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis
Identifieur interne : 001930 ( Main/Exploration ); précédent : 001929; suivant : 001931Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis
Auteurs : Marie Favennec [France] ; Benjamin Hennart [France] ; Marie Verbanck [France] ; Marie Pigeyre [France] ; Robert Caiazzo [France] ; Violeta Raverdy [France] ; Hélène Verkindt [France] ; Audrey Leloire [France] ; Gilles J. Guillemin [Australie] ; Loïc Yengo [France] ; Delphine Allorge [France] ; Philippe Froguel [France, Royaume-Uni] ; François Pattou [France] ; Odile Poulain-Godefroy [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Glucose, Protéine C-réactive.
- sang : Acide quinolinique, Cynurénine, Diabète, Sérotonine, Tryptophane, Xanthurénates.
- Adulte, Chirurgie bariatrique, Femelle, Homéostasie, Humains, Métabolome.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Kynurenine, Quinolinic Acid, Serotonin, Tryptophan, Xanthurenates.
- chemical , metabolism : C-Reactive Protein, Glucose.
- blood : Diabetes Mellitus.
- Adult, Bariatric Surgery, Female, Homeostasis, Humans, Metabolome.
Abstract
An increase of plasma kynurenine concentrations, potentially bioactive metabolites of tryptophan, was found in subjects with obesity, resulting from low-grade inflammation of the white adipose tissue. Bariatric surgery decreases low-grade inflammation associated with obesity and improves glucose control.
Our goal was to determine the concentrations of all kynurenine metabolites after bariatric surgery and whether they were correlated with glucose control improvement.
Kynurenine metabolite concentrations, analysed by liquid or gas chromatography coupled with tandem mass spectrometry, circulating inflammatory markers, metabolic traits, and BMI were measured before and one year after bariatric surgery in 44 normoglycemic and 47 diabetic women with obesity. Associations between changes in kynurenine metabolites concentrations and in glucose control and metabolic traits were analysed between baseline and twelve months after surgery.
Tryptophan and kynurenine metabolite concentrations were significantly decreased one year after bariatric surgery and were correlated with the decrease of the usCRP in both groups. Among all the kynurenine metabolites evaluated, only quinolinic acid and xanthurenic acid were significantly associated with glucose control improvement. The one year delta of quinolinic acid concentrations was negatively associated with the delta of fasting glucose (p = 0.019) and HbA1c (p = 0.014), whereas the delta of xanthurenic acid was positively associated with the delta of insulin sensitivity index (p = 0.0018).
Bariatric surgery has induced a global down-regulation of kynurenine metabolites, associated with weight loss. Our results suggest that, since kynurenine monoxygenase diverts the kynurenine pathway toward the synthesis of xanthurenic acid, its inhibition may also contribute to glucose homeostasis.
Url:
DOI: 10.1371/journal.pone.0158051
PubMed: 27327770
PubMed Central: 4915629
Affiliations:
- Australie, France, Royaume-Uni
- Angleterre, Grand Londres, Hauts-de-France, Nord-Pas-de-Calais
- Lille, Londres
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Le document en format XML
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Lille, U1190 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. 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Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Neuroinflammation group, Macquarie University, Sydney, NSW, 2109 Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroinflammation group, Macquarie University, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Univ. Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Univ. Lille, EA 4483 - IMPECS - IMPact de l’Environnement Chimique sur la Santé humaine, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, EA 4483 - IMPECS - IMPact de l’Environnement Chimique sur la Santé humaine, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>CHU Lille, Service de Toxicologie-Génopathies, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Lille, Service de Toxicologie-Génopathies, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Univ. Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="François" last="Pattou">François Pattou</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Univ. Lille, U1190 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. 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Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. 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Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Univ. Lille, EA 4483 - IMPECS - IMPact de l’Environnement Chimique sur la Santé humaine, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, EA 4483 - IMPECS - IMPact de l’Environnement Chimique sur la Santé humaine, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>CHU Lille, Service de Toxicologie-Génopathies, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Lille, Service de Toxicologie-Génopathies, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Verbanck, Marie" sort="Verbanck, Marie" uniqKey="Verbanck M" first="Marie" last="Verbanck">Marie Verbanck</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Univ. Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pigeyre, Marie" sort="Pigeyre, Marie" uniqKey="Pigeyre M" first="Marie" last="Pigeyre">Marie Pigeyre</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Univ. Lille, U1190 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, U1190 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Inserm, U1190, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1190, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Caiazzo, Robert" sort="Caiazzo, Robert" uniqKey="Caiazzo R" first="Robert" last="Caiazzo">Robert Caiazzo</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Univ. Lille, U1190 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, U1190 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Inserm, U1190, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1190, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Raverdy, Violeta" sort="Raverdy, Violeta" uniqKey="Raverdy V" first="Violeta" last="Raverdy">Violeta Raverdy</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Univ. Lille, U1190 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, U1190 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Inserm, U1190, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1190, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Verkindt, Helene" sort="Verkindt, Helene" uniqKey="Verkindt H" first="Hélène" last="Verkindt">Hélène Verkindt</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Univ. Lille, U1190 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, U1190 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Inserm, U1190, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1190, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Univ. Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Neuroinflammation group, Macquarie University, Sydney, NSW, 2109 Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroinflammation group, Macquarie University, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Univ. Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Univ. Lille, EA 4483 - IMPECS - IMPact de l’Environnement Chimique sur la Santé humaine, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, EA 4483 - IMPECS - IMPact de l’Environnement Chimique sur la Santé humaine, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>CHU Lille, Service de Toxicologie-Génopathies, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Lille, Service de Toxicologie-Génopathies, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Univ. Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="François" last="Pattou">François Pattou</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Univ. Lille, U1190 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, U1190 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Inserm, U1190, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1190, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Lille, Chirurgie générale et endocrinienne, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Univ. Lille, UMR 8199 - EGID, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, UMR 8199 - EGID, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>CNRS, UMR 8199, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 8199, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institut Pasteur de Lille, F-59000 Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Bariatric Surgery</term><term>C-Reactive Protein (metabolism)</term><term>Diabetes Mellitus (blood)</term><term>Female</term><term>Glucose (metabolism)</term><term>Homeostasis</term><term>Humans</term><term>Kynurenine (blood)</term><term>Metabolome</term><term>Quinolinic Acid (blood)</term><term>Serotonin (blood)</term><term>Tryptophan (blood)</term><term>Xanthurenates (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide quinolinique (sang)</term><term>Adulte</term><term>Chirurgie bariatrique</term><term>Cynurénine (sang)</term><term>Diabète (sang)</term><term>Femelle</term><term>Glucose (métabolisme)</term><term>Homéostasie</term><term>Humains</term><term>Métabolome</term><term>Protéine C-réactive (métabolisme)</term><term>Sérotonine (sang)</term><term>Tryptophane (sang)</term><term>Xanthurénates (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Kynurenine</term><term>Quinolinic Acid</term><term>Serotonin</term><term>Tryptophan</term><term>Xanthurenates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term><term>Glucose</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Diabetes Mellitus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glucose</term><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Acide quinolinique</term><term>Cynurénine</term><term>Diabète</term><term>Sérotonine</term><term>Tryptophane</term><term>Xanthurénates</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Bariatric Surgery</term><term>Female</term><term>Homeostasis</term><term>Humans</term><term>Metabolome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Chirurgie bariatrique</term><term>Femelle</term><term>Homéostasie</term><term>Humains</term><term>Métabolome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>An increase of plasma kynurenine concentrations, potentially bioactive metabolites of tryptophan, was found in subjects with obesity, resulting from low-grade inflammation of the white adipose tissue. Bariatric surgery decreases low-grade inflammation associated with obesity and improves glucose control.</p></sec><sec id="sec002"><title>Objective</title><p>Our goal was to determine the concentrations of all kynurenine metabolites after bariatric surgery and whether they were correlated with glucose control improvement.</p></sec><sec id="sec003"><title>Design</title><p>Kynurenine metabolite concentrations, analysed by liquid or gas chromatography coupled with tandem mass spectrometry, circulating inflammatory markers, metabolic traits, and BMI were measured before and one year after bariatric surgery in 44 normoglycemic and 47 diabetic women with obesity. Associations between changes in kynurenine metabolites concentrations and in glucose control and metabolic traits were analysed between baseline and twelve months after surgery.</p></sec><sec id="sec004"><title>Results</title><p>Tryptophan and kynurenine metabolite concentrations were significantly decreased one year after bariatric surgery and were correlated with the decrease of the usCRP in both groups. Among all the kynurenine metabolites evaluated, only quinolinic acid and xanthurenic acid were significantly associated with glucose control improvement. The one year delta of quinolinic acid concentrations was negatively associated with the delta of fasting glucose (p = 0.019) and HbA1c (p = 0.014), whereas the delta of xanthurenic acid was positively associated with the delta of insulin sensitivity index (p = 0.0018).</p></sec><sec id="sec005"><title>Conclusion</title><p>Bariatric surgery has induced a global down-regulation of kynurenine metabolites, associated with weight loss. Our results suggest that, since kynurenine monoxygenase diverts the kynurenine pathway toward the synthesis of xanthurenic acid, its inhibition may also contribute to glucose homeostasis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Olefsky, Jm" uniqKey="Olefsky J">JM Olefsky</name></author><author><name sortKey="Glass, Ck" uniqKey="Glass C">CK Glass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robinson, Cm" uniqKey="Robinson C">CM Robinson</name></author><author><name sortKey="Hale, Pt" uniqKey="Hale P">PT Hale</name></author><author><name sortKey="Carlin, Jm" uniqKey="Carlin J">JM Carlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brandacher, G" uniqKey="Brandacher G">G Brandacher</name></author><author><name sortKey="Winkler, C" uniqKey="Winkler C">C Winkler</name></author><author><name sortKey="Aigner, F" uniqKey="Aigner F">F 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Oxenkrug</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li><li>Londres</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Favennec, Marie" sort="Favennec, Marie" uniqKey="Favennec M" first="Marie" last="Favennec">Marie Favennec</name></region><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><name sortKey="Caiazzo, Robert" sort="Caiazzo, Robert" uniqKey="Caiazzo R" first="Robert" last="Caiazzo">Robert Caiazzo</name><name sortKey="Caiazzo, Robert" sort="Caiazzo, Robert" uniqKey="Caiazzo R" first="Robert" last="Caiazzo">Robert Caiazzo</name><name sortKey="Caiazzo, Robert" sort="Caiazzo, Robert" uniqKey="Caiazzo R" first="Robert" last="Caiazzo">Robert Caiazzo</name><name sortKey="Favennec, Marie" sort="Favennec, Marie" uniqKey="Favennec M" first="Marie" last="Favennec">Marie Favennec</name><name sortKey="Favennec, Marie" sort="Favennec, Marie" uniqKey="Favennec M" first="Marie" last="Favennec">Marie Favennec</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="François" last="Pattou">François Pattou</name><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="François" last="Pattou">François Pattou</name><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="François" last="Pattou">François Pattou</name><name sortKey="Pigeyre, Marie" sort="Pigeyre, Marie" uniqKey="Pigeyre M" first="Marie" last="Pigeyre">Marie Pigeyre</name><name sortKey="Pigeyre, Marie" sort="Pigeyre, Marie" uniqKey="Pigeyre M" first="Marie" last="Pigeyre">Marie Pigeyre</name><name sortKey="Pigeyre, Marie" sort="Pigeyre, Marie" uniqKey="Pigeyre M" first="Marie" last="Pigeyre">Marie Pigeyre</name><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><name sortKey="Raverdy, Violeta" sort="Raverdy, Violeta" uniqKey="Raverdy V" first="Violeta" last="Raverdy">Violeta Raverdy</name><name sortKey="Raverdy, Violeta" sort="Raverdy, Violeta" uniqKey="Raverdy V" first="Violeta" last="Raverdy">Violeta Raverdy</name><name sortKey="Raverdy, Violeta" sort="Raverdy, Violeta" uniqKey="Raverdy V" first="Violeta" last="Raverdy">Violeta Raverdy</name><name sortKey="Verbanck, Marie" sort="Verbanck, Marie" uniqKey="Verbanck M" first="Marie" last="Verbanck">Marie Verbanck</name><name sortKey="Verbanck, Marie" sort="Verbanck, Marie" uniqKey="Verbanck M" first="Marie" last="Verbanck">Marie Verbanck</name><name sortKey="Verbanck, Marie" sort="Verbanck, Marie" uniqKey="Verbanck M" first="Marie" last="Verbanck">Marie Verbanck</name><name sortKey="Verkindt, Helene" sort="Verkindt, Helene" uniqKey="Verkindt H" first="Hélène" last="Verkindt">Hélène Verkindt</name><name sortKey="Verkindt, Helene" sort="Verkindt, Helene" uniqKey="Verkindt H" first="Hélène" last="Verkindt">Hélène Verkindt</name><name sortKey="Verkindt, Helene" sort="Verkindt, Helene" uniqKey="Verkindt H" first="Hélène" last="Verkindt">Hélène Verkindt</name><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loïc" last="Yengo">Loïc Yengo</name></country><country name="Australie"><noRegion><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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